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Sleep. 2013 Jun 1;36(6):873-80. doi: 10.5665/sleep.2714.

Association of sleep disordered breathing and cognitive deficit in APOE ε4 carriers.

Author information

1
Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI 53726, USA.

Abstract

STUDY OBJECTIVES:

The aim of the study was to determine whether apolipoprotein E epsilon 4 genotype (APOE4) modifies the association of sleep disordered breathing (SDB) with cognitive function in a middle-aged population.

DESIGN:

Cross-sectional analysis of a community-dwelling cohort.

SETTINGS:

Sleep laboratory at the Clinical Research Unit of the University of Wisconsin Hospitals and Clinics.

PARTICIPANTS:

There were 755 adults from the Wisconsin Sleep Cohort who provided a total of 1,843 polysomnography and cognitive evaluations (most participants were assessed multiple times at approximately 4-y intervals); 56% males, average age 53.9 years (range 30-81 years).

INTERVENTIONS:

None.

MEASUREMENT AND RESULTS:

In-laboratory overnight polysomnography was used to assess SDB. Cognition was evaluated by a battery of six neurocognitive tests assessing memory and learning, attention, executive function, and psychomotor efficiency. The APOE4 genotype (ε3/ε4 or ε4/ ε4) was identified in 200 participants. Data were analyzed using linear mixed-effects models, accounting for multiple observations per participant. Cognitive test scores were regressed on SDB categories (AHI < 5, 5 ≤ AHI < 15, AHI ≥ 15); APOE4 and their interaction; and age, education, sex, and body mass index. There was no statistically significant association between SDB and cognitive performance among APOE4-negative individuals. However, in APOE4-positive individuals, those with AHI ≥ 15 had significantly worse performance on the Auditory Verbal Learning Test and the Controlled Oral Word Association Test.

CONCLUSIONS:

In APOE4-positive individuals, moderate to severe sleep disordered breathing (AHI ≥ 15) was associated with poorer performance on cognitive tests that require both memory and executive function engagement.

KEYWORDS:

APOE4; cognitive deficit; sleep apnea

PMID:
23729930
PMCID:
PMC3649829
DOI:
10.5665/sleep.2714
[Indexed for MEDLINE]
Free PMC Article

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