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J Pediatr Endocrinol Metab. 2013;26(9-10):813-7. doi: 10.1515/jpem-2013-0075.

The arginine stimulation test: timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency.

Abstract

BACKGROUND:

A typical peak timing in the glucagon stimulation test has been reported as an indication of growth hormone (GH) deficiency. Other stimulation tests have not been evaluated.

OBJECTIVE:

To evaluate the clinical usefulness of peak timing in the arginine stimulation test (AST) for growth hormone deficiency.

METHODS:

Retrospective review of 199 ASTs from one center. Outcomes included correlation of peak times with (a) frequency of deficient peak; (b) growth velocity standard deviation scores (GVSDSs); (c) other evidence of pituitary pathology; (d) results of confirmatory clonidine test; and (e) response to GH treatment.

RESULTS:

The peak in 83/109 (76.14%) sufficient tests occurred at typical times vs. 45/72 (62.5%) deficient tests (p<0.05). GVSDS on GH treatment was greater among patients with typical timing in the AST compared with atypical timing (2.67 ± 0.59 vs. 0.46 ± 1.17, p=0.021). No other variable correlated significantly with AST timing.

CONCLUSIONS:

Timing of peak in the AST is not a clinically useful parameter.

PMID:
23729606
DOI:
10.1515/jpem-2013-0075
[Indexed for MEDLINE]
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