YAP forces fibroblasts to feel the tension

Nat Cell Biol. 2013 Jun;15(6):570-2. doi: 10.1038/ncb2777.

Abstract

Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and remodelling. However, how CAFs become activated and their roles in tumour mechanics have remained unclear. YAP is now identified as a tension-stimulated CAF activator that promotes malignancy through a mechanically reinforced feed-forward loop.

Publication types

  • News
  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Breast Neoplasms / metabolism*
  • Cell Cycle Proteins
  • Female
  • Fibroblasts / physiology*
  • Humans
  • Mechanotransduction, Cellular*
  • Phosphoproteins / metabolism*
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Cell Cycle Proteins
  • Phosphoproteins
  • YAP-Signaling Proteins
  • Yap1 protein, mouse