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Clin Infect Dis. 2013 Sep;57(6):849-52. doi: 10.1093/cid/cit376. Epub 2013 May 31.

Central nervous system herpes simplex and varicella zoster virus infections in natalizumab-treated patients.

Author information

1
US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Silver Spring, MD 20993, USA. andrew.fine@fda.hhs.gov

Abstract

We report on 20 natalizumab-treated patients with multiple sclerosis who developed laboratory-confirmed central nervous system (CNS) herpesvirus infections. In addition to progressive multifocal leukoencephalopathy, other CNS opportunistic infections have been rarely reported during natalizumab treatment. We encourage heightened awareness due to the risk for serious outcomes.

KEYWORDS:

HSV; VZV; encephalitis; meningitis; natalizumab

PMID:
23728144
DOI:
10.1093/cid/cit376
[Indexed for MEDLINE]

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