Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2

Cancer Genet Cytogenet. 1990 Aug 1;48(1):101-7. doi: 10.1016/0165-4608(90)90222-v.

Abstract

Short-term cultures of two myxoid liposarcomas and two mixed-type (myxoid and round cell) liposarcomas were cytogenetically analyzed. A t(12;16)(q13;p11) was present in three tumors, whereas the fourth had an unbalanced 12;16-translocation with breaks in 12q13 and 12q22, with loss of the 12q13-q22 segment, and in 16p11. In the two mixed liposarcomas, the breakpoints could be determined at subband level to 12q13.3 and 16p11.2.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromosome Banding
  • Chromosomes, Human, Pair 12*
  • Chromosomes, Human, Pair 16*
  • Female
  • Genetic Markers
  • Humans
  • Karyotyping
  • Liposarcoma / genetics*
  • Liposarcoma / pathology
  • Male
  • Middle Aged
  • Translocation, Genetic*

Substances

  • Genetic Markers