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Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:130-8. doi: 10.1016/j.prostaglandins.2013.05.002. Epub 2013 May 28.

The growing role of eicosanoids in tissue regeneration, repair, and wound healing.

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Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.


Tissue repair and regeneration are essential processes in maintaining tissue homeostasis, especially in response to injury or stress. Eicosanoids are ubiquitous mediators of cell proliferation, differentiation, and angiogenesis, all of which are important for tissue growth. Eicosanoids regulate the induction and resolution of inflammation that accompany the tissue response to injury. In this review, we describe how this diverse group of molecules is a key regulator of tissue repair and regeneration in multiple organ systems and biologic contexts.

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