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Alzheimers Dement. 2014 Mar;10(2):225-37. doi: 10.1016/j.jalz.2013.02.005. Epub 2013 May 30.

Diagnosing Alzheimer's disease: a systematic review of economic evaluations.

Author information

1
Alzheimer Centre Limburg, School for Mental Health and Neuroscience, University Medical Centre, Maastricht, The Netherlands. Electronic address: f.verhey@maastrichtuniversity.nl.
2
Alzheimer Centre Limburg, School for Mental Health and Neuroscience, University Medical Centre, Maastricht, The Netherlands.
3
Department of Health Organization, Policy, and Economics, CAPHRI School for Public Health and Primary Care, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
4
Institute of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.

Abstract

BACKGROUND:

The objective of this study is to systematically review the literature on economic evaluations of interventions for the early diagnosis of Alzheimer's disease (AD) and related disorders and to describe their general and methodological characteristics. We focused on the diagnostic aspects of the decision models to assess the applicability of existing decision models for the evaluation of the recently revised diagnostic research criteria for AD.

METHODS:

PubMed and the National Institute for Health Research Economic Evaluation database were searched for English-language publications related to economic evaluations on diagnostic technologies. Trial-based economic evaluations were assessed using the Consensus on Health Economic Criteria list. Modeling studies were assessed using the framework for quality assessment of decision-analytic models.

RESULTS:

The search retrieved 2109 items, from which eight decision-analytic modeling studies and one trial-based economic evaluation met all eligibility criteria.

CONCLUSIONS:

Diversity among the study objective and characteristics was considerable and, despite considerable methodological quality, several flaws were indicated. Recommendations were focused on diagnostic aspects and the applicability of existing models for the evaluation of recently revised diagnostic research criteria for AD.

KEYWORDS:

Alzheimer's disease; Biomarker; Cost-effectiveness; Costs; Decision-analytic model; Dementia; Diagnostic intervention; Early diagnosis; Economic evaluation; Health technology assessment; Modeling; Neurodegenerative disorder; Quality assessment; Review

PMID:
23727080
DOI:
10.1016/j.jalz.2013.02.005
[Indexed for MEDLINE]

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