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Cancer Lett. 2013 Aug 28;337(1):26-34. doi: 10.1016/j.canlet.2013.05.030. Epub 2013 May 29.

P97/CDC-48: proteostasis control in tumor cell biology.

Author information

1
Inserm U1045, Bordeaux, France.

Abstract

P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA+ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.

KEYWORDS:

CDC-48; Cancer; Proteostasis; VCP; p97

PMID:
23726843
DOI:
10.1016/j.canlet.2013.05.030
[Indexed for MEDLINE]

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