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Clin Biochem. 2013 Aug;46(12):1131-4. doi: 10.1016/j.clinbiochem.2013.05.052. Epub 2013 May 29.

Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure.

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1
Department of Pathology, The University of Virginia Health System, Charlottesville, VA 22908, USA.

Erratum in

  • Clin Biochem. 2014 Apr;47(6):501.

Abstract

OBJECTIVES:

To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake.

DESIGN AND METHODS:

Human urinary exosomal miRNome was examined by microarray.

RESULTS:

Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity.

CONCLUSION:

The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium.

KEYWORDS:

BP; Blood pressure; Exosome; ISS; MAP; SR; SS; Salt-resistant; Salt-sensitive; blood pressure; inverse salt-sensitive; mean arterial pressure; miRNA; salt-resistant; salt-sensitive

PMID:
23726803
PMCID:
PMC3786136
DOI:
10.1016/j.clinbiochem.2013.05.052
[Indexed for MEDLINE]
Free PMC Article
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