Format

Send to

Choose Destination
Trends Cell Biol. 2013 Sep;23(9):409-20. doi: 10.1016/j.tcb.2013.04.007. Epub 2013 May 30.

A cytoprotective perspective on longevity regulation.

Author information

1
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

There are many mechanisms of lifespan extension, including the disruption of insulin/insulin-like growth factor 1 (IGF-1) signaling, metabolism, translation, and feeding. Despite the disparate functions of these pathways, inhibition of each induces responses that buffer stress and damage. Here, emphasizing data from genetic analyses in Caenorhabditis elegans, we explore the effectors and upstream regulatory components of numerous cytoprotective mechanisms activated as major elements of longevity programs, including detoxification, innate immunity, proteostasis, and oxidative stress response. We show that their induction underpins longevity extension across functionally diverse triggers and across species. Intertwined with the evolution of longevity, cytoprotective pathways are coupled to the surveillance of core cellular components, with important implications in normal and aberrant responses to drugs, chemicals, and pathogens.

KEYWORDS:

aging; cytoprotection; detoxification; hormesis; longevity; stress

PMID:
23726168
PMCID:
PMC4057428
DOI:
10.1016/j.tcb.2013.04.007
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center