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Curr Opin Biotechnol. 2013 Oct;24(5):830-3. doi: 10.1016/j.copbio.2013.04.011. Epub 2013 May 28.

Extracellular matrix signaling in morphogenesis and repair.

Author information

1
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive NW, Atlanta, GA 30332, USA.

Abstract

The extracellular matrix (ECM) is critically important for many cellular processes including growth, differentiation, survival, and morphogenesis. Cells remodel and reshape the ECM by degrading and reassembling it, playing an active role in sculpting their surrounding environment and directing their own phenotypes. Both mechanical and biochemical molecules influence ECM dynamics in multiple ways; by releasing small bioactive signaling molecules, releasing growth factors stored within the ECM, eliciting structural changes to matrix proteins which expose cryptic sites and by degrading matrix proteins directly. The dynamic reciprocal communication between cells and the ECM plays a fundamental roll in tissue development, homeostasis, and wound healing.

PMID:
23726156
PMCID:
PMC3773047
DOI:
10.1016/j.copbio.2013.04.011
[Indexed for MEDLINE]
Free PMC Article

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