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Chin J Nat Med. 2013 May;11(3):309-13. doi: 10.1016/S1875-5364(13)60034-5.

Effect of diammonium glycyrrhizinate on entecavir pharmacokinetics in rats.

Author information

1
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.

Abstract

AIM:

This study was designed to explore the effects of short-term and long-term pretreatment of diammonium glycyrrhizinate (GLN) on the pharmacokinetics of entecavir (ETV) in rats.

METHODS:

Male SD rats were randomized into short-term and long-term experimental groups, respectively. In the short-term experiment, the control group received saline, the low dose group received GLN 13.5 mg·kg(-1) and the high dose group received GLN 40.5 mg·kg(-1). ETV (0.09 mg·kg(-1)) was given i.g. 0.5 h after saline/GLN administration. For the long-term experiment, rats were allocated into two experimental designs. The control group received saline/ETV (0.09 mg·kg(-1)), the low dose group received GLN 13.5 mg·kg(-1)/ETV 0.09 mg·kg(-1) + GLN 13.5 mg·kg(-1), while the high dose group received GLN 40.5 mg·kg(-1)/ETV 0.09 mg·kg(-1) + GLN 40.5 mg·kg(-1); all administration was continued for 15 days. On the 16(th) day, 0.09 mg·kg(-1) ETV was administrated to all groups. Blood samples were obtained at different time points after ETV administration to determine plasma ETV concentrations.

RESULTS:

Pretreatment with glycyrrhizin resulted in no significant alterations in the main pharmacokinetic parameters of ETV in the short-term and long-term administration experiments.

CONCLUSION:

Diammonium glycyrrhizinate has no effect on ETV pharmacokinetics in rats.

PMID:
23725847
DOI:
10.1016/S1875-5364(13)60034-5
[Indexed for MEDLINE]

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