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Neth J Med. 2013 May;71(4):199-202.

High-dose methylprednisolone-induced hepatitis in a patient with multiple sclerosis: a case report and brief review of literature.

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Department of Gastroenterology and Hepatology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands.


Toxic hepatitis is a rare but serious complication of high-dose prednisolone treatment. We report a case of high-dose prednisolone-induced acute hepatitis in a 48-year-old woman suffering from multiple sclerosis that recurred after repeated administration. Timely recognition is paramount to avoid this complication. This report includes a brief review of the literature on methylprednisolone- induced hepatitis.

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