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Nat Methods. 2013 Jun;10(6):508-13. doi: 10.1038/nmeth.2481.

CLARITY for mapping the nervous system.

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1
Department of Bioengineering, Stanford University, Stanford, California, USA. khchung@mit.edu

Erratum in

  • Nat Methods. 2013 Oct;10(10):1035.

Abstract

With potential relevance for brain-mapping work, hydrogel-based structures can now be built from within biological tissue to allow subsequent removal of lipids without mechanical disassembly of the tissue. This process creates a tissue-hydrogel hybrid that is physically stable, that preserves fine structure, proteins and nucleic acids, and that is permeable to both visible-spectrum photons and exogenous macromolecules. Here we highlight relevant challenges and opportunities of this approach, especially with regard to integration with complementary methodologies for brain-mapping studies.

PMID:
23722210
DOI:
10.1038/nmeth.2481
[Indexed for MEDLINE]
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