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Front Neural Circuits. 2013 May 15;7:92. doi: 10.3389/fncir.2013.00092. eCollection 2013.

Motor directional tuning across brain areas: directional resonance and the role of inhibition for directional accuracy.

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Graduate Program in Biomedical Informatics and Computational Biology, University of Minnesota Minneapolis, MN, USA.


Motor directional tuning (Georgopoulos et al., 1982) has been found in every brain area in which it has been sought for during the past 30-odd years. It is typically broad, with widely distributed preferred directions and a population signal that predicts accurately the direction of an upcoming reaching movement or isometric force pulse (Georgopoulos et al., 1992). What is the basis for such ubiquitous directional tuning? How does the tuning come about? What are the implications of directional tuning for understanding the brain mechanisms of movement in space? This review addresses these questions in the light of accumulated knowledge in various sub-fields of neuroscience and motor behavior. It is argued (a) that direction in space encompasses many aspects, from vision to muscles, (b) that there is a directional congruence among the central representations of these distributed "directions" arising from rough but orderly topographic connectivities among brain areas,


directional precision; inhibitory mechanisms; motor directional tuning; motor resonance; movement direction

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