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J Magn Reson Imaging. 2014 Feb;39(2):307-16. doi: 10.1002/jmri.24171. Epub 2013 May 29.

MR characterization of hepatic storage iron in transfusional iron overload.

Author information

1
Imaging, Discovery Medicine & Clinical Pharmacology, Bristol Myers Squibb, Princeton, New Jersey, USA.

Abstract

PURPOSE:

To quantify the two principal forms of hepatic storage iron, diffuse, soluble iron (primarily ferritin), and aggregated, insoluble iron (primarily hemosiderin) using a new MRI method in patients with transfusional iron overload.

MATERIALS AND METHODS:

Six healthy volunteers and 20 patients with transfusion-dependent thalassemia syndromes and iron overload were examined. Ferritin- and hemosiderin-like iron were determined based on the measurement of two distinct relaxation parameters: the "reduced" transverse relaxation rate, RR2 , and the "aggregation index," A, using three sets of Carr-Purcell-Meiboom-Gill (CPMG) datasets with different interecho spacings. Agarose phantoms, simulating the relaxation and susceptibility properties of tissue with different concentrations of dispersed (ferritin-like) and aggregated (hemosiderin-like) iron, were used for validation.

RESULTS:

Both phantom and in vivo human data confirmed that transverse relaxation components associated with the dispersed and aggregated iron could be separated using the two-parameter (RR2 , A) method. The MRI-determined total hepatic storage iron was highly correlated (r = 0.95) with measurements derived from biopsy or biosusceptometry. As total hepatic storage iron increased, the proportion stored as aggregated iron became greater.

CONCLUSION:

This method provides a new means for noninvasive MRI determination of the partition of hepatic storage iron between ferritin and hemosiderin in iron overload disorders.

KEYWORDS:

MRI; ferritin, hemosiderin, iron quantification; hepatic storage iron; iron overload

PMID:
23720394
PMCID:
PMC3761000
DOI:
10.1002/jmri.24171
[Indexed for MEDLINE]
Free PMC Article

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