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Compr Physiol. 2013 Apr;3(2):957-76. doi: 10.1002/cphy.c120028.

Immune and inflammatory role in renal disease.

Author information

1
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. jdimig@mcw.edu

Abstract

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and immune system activation as a common underlying mechanism. The purpose of this review is to provide a broad overview of immune cells and inflammatory proteins that contribute to the pathogenesis of renal disease, and to discuss some of the physiological changes that occur in the kidney as a result of immune system activation. An overview of common forms of acute and chronic renal disease is provided, followed by a discussion of common therapies that have anti-inflammatory or immunosuppressive effects in the treatment of renal disease.

PMID:
23720336
PMCID:
PMC3803162
DOI:
10.1002/cphy.c120028
[Indexed for MEDLINE]
Free PMC Article

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