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Neuron. 2013 May 22;78(4):583-95. doi: 10.1016/j.neuron.2013.05.006.

Mapping and cracking sensorimotor circuits in genetic model organisms.

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1
Department of Neurobiology, 299 W. Campus Drive, Stanford University, Stanford, CA 94305, USA.

Abstract

One central goal of systems neuroscience is to understand how neural circuits implement the computations that link sensory inputs to behavior. Work combining electrophysiological and imaging-based approaches to measure neural activity with pharmacological and electrophysiological manipulations has provided fundamental insights. More recently, genetic approaches have been used to monitor and manipulate neural activity, opening up new experimental opportunities and challenges. Here, we discuss issues associated with applying genetic approaches to circuit dissection in sensorimotor transformations, outlining important considerations for experimental design and considering how modeling can complement experimental approaches.

PMID:
23719159
PMCID:
PMC4023671
DOI:
10.1016/j.neuron.2013.05.006
[Indexed for MEDLINE]
Free PMC Article
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