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J Pediatric Infect Dis Soc. 2013 Jun;2(2):100-9. doi: 10.1093/jpids/pit012. Epub 2013 Apr 10.

Consensus Statement on Research Definitions for Drug-Resistant Tuberculosis in Children.

Author information

1
Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.
2
Grupo Tuberculosis Valle-Colorado, and Clínica León XIII IPS Universidad de Antioquia, Medellín, Antioquia, Colombia.
3
Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Tygerberg Children's Hospital, Cape Town, South Africa.
4
Division of Infectious Diseases, TB Research Unit, Case Western Reserve University School of Medicine, Cleveland, Ohio.
5
Sydney Institute for Emerging Infectious Diseases and Biosecurity, and The Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Australia.
6
Academic Unit of Clinical and Experimental Science, Faculty of Medicine, and Institute for Life Sciences, University of Southampton, United Kingdom Department of Paediatrics, Faculty of Medicine, University of Melbourne, Australia.
7
The International Union Against Tuberculosis and Lung Disease, New York, and.
8
Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
9
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York.
10
Section of Infectious Disease and International Health, Global Health Initiative, Dartmouth Medical School, Hanover, New Hampshire.
11
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
12
National Institute for Research in Tuberculosis, Chennai, India.
13
Department of Global Health and Social Medicine, Harvard Medical School Partners In Health, Boston, Massachusetts.

Abstract

Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. The World Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DR-TB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome.

KEYWORDS:

Children; Consensus; Definition; Drug-Resistance; Pediatric; Tuberculosis

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