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PLoS One. 2013 May 22;8(5):e64249. doi: 10.1371/journal.pone.0064249. Print 2013.

Routine CSF analysis in coccidioidomycosis is not required.

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1
Coccidioidomycosis Serology Laboratory, Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America. grthompson@ucdavis.edu

Abstract

Although routinely done, there has been no evaluation of the utility of performing routine cerebrospinal fluid (CSF) examination in patients with active coccidioidomycosis and high complement fixation (IgG) antibody titers or other risk factors for disseminated infection. In our review 100% of patients diagnosed with coccidioidal meningitis had at least one sign or symptom consistent with infection of the central nervous system, headache was present in 100% of those with meningitis, while no patients without signs/symptoms of CNS infection were found to have coccidioidal meningitis, irrespective of antibody titers or other risk factors. Thus routine lumbar puncture may be unnecessary for patients with coccidioidomycosis who lack suggestive clinical symptoms.

PMID:
23717579
PMCID:
PMC3661666
DOI:
10.1371/journal.pone.0064249
[Indexed for MEDLINE]
Free PMC Article
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