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Development. 2013 Jun;140(12):2502-12. doi: 10.1242/dev.084210.

Tumor suppressors: enhancers or suppressors of regeneration?

Author information

1
Department of Surgery, Division of Plastic and Reconstructive Surgery, University of California, San Francisco, CA 94143, USA. jason.pomerantz@ucsfmedctr.org

Abstract

Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essential for tissue regeneration. This is in contrast to suggestions that tumor suppression is a trade-off for regenerative capacity. We also hypothesize that certain aspects of tumor suppressor pathways inhibit regenerative processes in mammals, and that transient targeted modification of these pathways could be fruitfully exploited to enhance processes that are important to regenerative medicine.

KEYWORDS:

Differentiation; Evolution; Regeneration; Tissue homeostasis; Tumor suppressors

PMID:
23715544
PMCID:
PMC3666379
DOI:
10.1242/dev.084210
[Indexed for MEDLINE]
Free PMC Article

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