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Heart Lung. 2013 Jul-Aug;42(4):251-6. doi: 10.1016/j.hrtlng.2013.03.006. Epub 2013 May 25.

Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials.

Author information

1
Department of Cardiology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756-0001, USA. khoueiry_gm@hotmail.com

Abstract

INTRODUCTION:

Omega-3 polyunsaturated fatty acids (PUFA) have demonstrated to have antiarrhythmic properties. However, randomized studies have shown inconsistent results.

OBJECTIVE:

We aimed to analyze the effect of omega-3 PUFA on preventing potentially fatal ventricular arrhythmias and sudden cardiac death.

METHODS:

Randomized trials comparing omega-3 PUFA to placebo and reporting sudden cardiac death (SCD) or first implanted cardioverter-defibrillator (ICD) event for ventricular tachycardia or fibrillation were included in this study. A meta-analysis using a random effects model was performed and results were expressed in terms of Odds Ratio (OR) and 95% Confidence Interval (CI) after evaluating for interstudy heterogeneity using I(2). The reported data were extracted on the basis of the intention-to-treat principle.

RESULTS:

A total of 32,919 patients were included in nine trials; 16,465 patients received omega-3 PUFA and 16,454 received placebo. When comparing omega-3 PUFA to placebo, there was nonsignificant risk reduction of SCD or ventricular arrhythmias (OR = 0.82 [95% CI: 0.60-1.21], p = 0.21 I(2) = 49.7%).

CONCLUSION:

Dietary supplementation with omega-3 PUFA does not affect the risk of SCD or ventricular arrhythmias.

KEYWORDS:

Arrhythmias; Dietary supplements; Fish oil; Sudden cardiac death

PMID:
23714269
DOI:
10.1016/j.hrtlng.2013.03.006
[Indexed for MEDLINE]

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