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Asia Pac J Clin Oncol. 2016 Mar;12(1):e75-81. doi: 10.1111/ajco.12084. Epub 2013 May 29.

The impact of type 2 diabetes mellitus on mortality in hospitalized female cancer patients in Taiwan.

Author information

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan Hsien, Taiwan.
  • 2Department of Industrial Design, Healthy Aging Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan Hsien, Taiwan.

Abstract

INTRODUCTION:

The goal of this study was to determine the relationships among type 2 diabetes mellitus (DM), specific cancer histological types and mortality in hospitalized women.

METHODS:

Patients over 19 years of age were included if the indication for hospital admission was a diagnosis of type 2 DM or a malignancy. In total, 67,660 female patients with a mean age 62.76 ± 14.48 years were enrolled. These patients were categorized into the following three groups: patients with cancer but without type 2 DM (group A); patients with cancer and type 2 DM (group B) and patients with type 2 DM but without cancer (group C). Attributable fractions (AF) were calculated as ([hazard ratio - 1]/hazard ratio) × 100 to evaluate the impact of type 2 DM on mortality for specific cancers.

RESULTS:

Of the study participants, 37,204 (55%) were diagnosed with type 2 DM. The patients were categorized as follows: group A, 30,456 patients; group B, 5992 patients and group C, 31,212 patients. Group B patients had high frequencies of pancreatic, liver and renal cancers and low frequencies of thyroid, breast and ovarian cancers. Of the 36,448 cancer patients, 2906 (8%) died. The mortality rate in group B (10 %) was significantly higher than that in groups A and C. Type 2 DM was associated with increased mortality and AF for thyroid, nasopharyngeal, urinary tract, ovarian, breast and cervical cancers (hazard ratio over 1.50).

CONCLUSION:

The incidence of type 2 DM in patients with different histological types of cancer varied widely, ranging from 8-34%. Among the cancer patients, type 2 DM had a significantly greater impact on the mortality rates of patients with cancers associated with relatively low mortality.

KEYWORDS:

cancer mortality; hepatoma; hyperinsulinemia; pancreatic cancer

PMID:
23714100
DOI:
10.1111/ajco.12084
[PubMed - indexed for MEDLINE]
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