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Adv Mater. 2013 Jul 12;25(26):3599-604. doi: 10.1002/adma.201300823. Epub 2013 May 28.

Enzyme-directed assembly of a nanoparticle probe in tumor tissue.

Author information

1
Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

KEYWORDS:

enzyme-responsive; in vivo probe; micelle; nanoparticles; peptide

PMID:
23712821
PMCID:
PMC4108424
DOI:
10.1002/adma.201300823
[Indexed for MEDLINE]
Free PMC Article
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