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Nat Rev Urol. 2013 Jul;10(7):405-13. doi: 10.1038/nrurol.2013.110. Epub 2013 May 28.

Hypoxia, notch signalling, and prostate cancer.

Author information

1
Radiation and Urologic Oncology, Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, Trinity Centre for Health Sciences, James's Street, Dublin 8, Ireland. marignol@tcd.ie

Abstract

The notch signalling pathway is involved in differentiation, proliferation, angiogenesis, vascular remodelling, and apoptosis. Deregulated expression of notch receptors, ligands, and targets is observed in many solid tumours, including prostate cancer. Hypoxia is a common feature of prostate tumours, leading to increased gene instability, reduced treatment response, and increased tumour aggressiveness. The notch signalling pathway is known to regulate vascular cell fate and is responsive to hypoxia-inducible factors. Evidence to date suggests similar, therapeutically exploitable, behaviour of notch-activated and hypoxic prostate cancer cells.

PMID:
23712204
PMCID:
PMC5240418
DOI:
10.1038/nrurol.2013.110
[Indexed for MEDLINE]
Free PMC Article

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