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J Cataract Refract Surg. 2013 Aug;39(8):1141-5. doi: 10.1016/j.jcrs.2013.01.045. Epub 2013 May 24.

Effective corneal collagen crosslinking in advanced cases of progressive keratoconus.

Author information

1
Department of Ophthalmology, University Medical Center Utrecht, the Netherlands.

Abstract

PURPOSE:

To evaluate the 1-year results of corneal collagen crosslinking (CXL) in mild to moderate cases and advanced cases of progressive keratoconus.

SETTING:

Department of Ophthalmology, University Medical Center Utrecht, the Netherlands.

DESIGN:

Retrospective cohort study.

METHODS:

Eyes with progressive keratoconus had CXL between January 2010 and April 2011. Patients were divided into 2 subgroups as follows: Group 1, mild to moderate keratoconus with a preoperative maximum keratometry (K) of less than 58.0 diopters (D), and Group 2, advanced keratoconus with a maximum K of 58.0 D or more. Visual acuity, refraction, and elevation-based topography were evaluated at baseline and 12 months after CXL.

RESULTS:

The study comprised 53 eyes of 42 patients. In the overall group, progression was halted in 48 eyes (91%). The CXL-induced corneal flattening occurred in 11 (42%) of 26 eyes in Group 1 and 20 (74%) of 27 eyes in Group 2. Five of 7 keratoconus indices improved 12 months after CXL. The failure rate was comparable in the subgroups (3 eyes in Group 1, 2 eyes in Group 2). No major complications occurred in either subgroup.

CONCLUSIONS:

Stabilization after CXL was achieved in mild to moderate cases and advanced cases of progressive keratoconus. The amount of failure was comparable in the 2 subgroups. The CXL-induced flattening was more pronounced in the advanced subgroup.

PMID:
23711873
DOI:
10.1016/j.jcrs.2013.01.045
[Indexed for MEDLINE]

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