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Heart Lung Circ. 2013 Nov;22(11):924-9. doi: 10.1016/j.hlc.2013.03.075. Epub 2013 May 25.

Low grade inflammation and ECG left ventricular hypertrophy in urban African males: The SABPA study.

Author information

1
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom Campus, Private Bag X6001, Potchefstroom, 2520, South Africa.

Abstract

BACKGROUND:

Hypertension and vascular hyperresponsiveness have been associated with structural wall abnormalities in black Africans. Whether low grade inflammation would have an additive effect is uncertain. Therefore, a novel investigation aimed to assess whether inflammation and pressure overload would have an additive association with ECG left ventricular hypertrophy (LVH).

METHODS:

We included 75 African and 87 Caucasian males. Ambulatory blood pressure monitoring was done in the working week. A resting 12-lead ECG recording was used for the determination of LVH with the Cornell product formula. Fasting blood samples were obtained for high sensitivity C-reactive protein (hs-CRP) analyses after a controlled overnight stay. Men were stratified into low (≤3 mg/L) and high (>3 mg/L) hs-CRP groups.

RESULTS:

African men revealed higher ambulatory blood pressure levels compared to Caucasian men independent of hs-CRP levels after adjustment for age, physical activity, cotinine, log γ-GT and body surface area. In forward stepwise linear regression analyses, SBP was positively associated with ECG LVH in all Africans. Considering low grade inflammatory status (>3 mg/L hs-CRP), SBP [Adj R(2)=0.49 (β=0.99, 0.45, 1.44), p≤0.01] and pulse pressure [Adj R(2)=0.61 (β=0.0.34, 0.88), p≤0.01] respectively, predicted ECG LVH in African but not in Caucasian men.

CONCLUSIONS:

Hyperdynamic blood pressure and inflammation acted in tandem as possible promoting factors to structural wall abnormalities in African men.

KEYWORDS:

Blood pressure; Ethnicity; Inflammation; Left ventricular hypertrophy

Comment in

PMID:
23711691
DOI:
10.1016/j.hlc.2013.03.075
[Indexed for MEDLINE]

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