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Clin Dev Immunol. 2013;2013:294320. doi: 10.1155/2013/294320. Epub 2013 Apr 22.

Interleukin-19 in breast cancer.

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1
Department of Medical Research, Chi-Mei Medical Center, Tainan 710, Taiwan.

Abstract

Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo. IL-19 has an autocrine effect in breast cancer cells. It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.

PMID:
23710200
PMCID:
PMC3654677
DOI:
10.1155/2013/294320
[Indexed for MEDLINE]
Free PMC Article
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