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ScientificWorldJournal. 2013 Apr 18;2013:808460. doi: 10.1155/2013/808460. Print 2013.

Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice.

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1
Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, Brazil. jackson.guedes@univasf.edu.br

Abstract

Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneol produced a significant (P < 0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reduced the writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose) produced an inhibition (P < 0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.

PMID:
23710149
PMCID:
PMC3654274
DOI:
10.1155/2013/808460
[Indexed for MEDLINE]
Free PMC Article
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