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J Nucl Med. 2013 Jul;54(7):1007-10. doi: 10.2967/jnumed.112.113100. Epub 2013 May 24.

Radiolabeled amino acids for oncologic imaging.

Author information

1
Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Abstract

Radiolabeled amino acids (AAs) are an important class of imaging agents for PET and SPECT that target the increased levels of AA transport by many tumor cells. System L AA transport has been a major focus of tracer development, and work in this field has led to several tracers that are effective for imaging brain tumors. Emerging data also support the use of certain radiolabeled AAs for neuroendocrine tumors and prostate cancer. Recently, new (18)F-labeled AAs have been developed that target transporters other than system L, including system A, glutamine, xCT, and cationic AA transporters. This review provides an overview of this class of molecular imaging agents and highlights the current status of oncologic imaging with radiolabeled AAs in terms of tracer considerations and key clinical applications.

KEYWORDS:

PET; SPECT; amino acids; tumor imaging

PMID:
23708197
DOI:
10.2967/jnumed.112.113100
[Indexed for MEDLINE]
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