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Rev Esp Med Nucl Imagen Mol. 2014 Jan-Feb;33(1):1-5. doi: 10.1016/j.remn.2013.03.005. Epub 2013 May 23.

Dual time point 2-deoxy-2-[18F]fluoro-D-glucose PET/CT: nodal staging in locally advanced breast cancer.

Author information

1
Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain. Electronic address: angarvice@yahoo.es.
2
Nuclear Medicine Department, University General Hospital, Ciudad Real, Spain.
3
Oncology Department, Virgen de la Salud Hospital, Toledo, Spain.
4
Oncology Department, Virgen de la Luz Hospital, Cuenca, Spain.
5
Oncology Department, La Mancha Centro Hospital, Alcázar de San Juan, Ciudad Real, Spain.
6
Investigation Unit, University General Hospital, Ciudad Real, Spain.
7
Oncology Department, Nuestra Sra. del Prado Hospital, Talavera de la Reina, Toledo, Spain.

Abstract

AIM:

To assess dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose (18)(F)FDG PET-CT accuracy in nodal staging and in detection of extra-axillary involvement.

MATERIAL AND METHODS:

Dual time point [(18)F] FDG PET/CT scan was performed in 75 patients. Visual and semiquantitative assessment of lymph nodes was performed. Semiquantitative measurement of SUV and ROC-analysis were carried out to calculate SUV(max) cut-off value with the best diagnostic performance. Axillary and extra-axillary lymph node chains were evaluated.

RESULTS:

Sensitivity and specificity of visual assessment was 87.3% and 75%, respectively. SUV(max) values with the best sensitivity were 0.90 and 0.95 for early and delayed PET, respectively. SUV(max) values with the best specificity were 1.95 and 2.75, respectively. Extra-axillary lymph node involvement was detected in 26.7%.

CONCLUSION:

FDG PET/CT detected extra-axillary lymph node involvement in one-fourth of the patients. Semiquantitative lymph node analysis did not show any advantage over the visual evaluation.

KEYWORDS:

(18)(F)FDG PET/CT; Cáncer de mama localmente avanzado; Dual time point PET; Estadificación ganglionar; Locally advanced breast cancer; Lymph node staging; PET en doble fase; [(18)F] FDG PET-TC

PMID:
23707190
DOI:
10.1016/j.remn.2013.03.005
[Indexed for MEDLINE]
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