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Trends Immunol. 2013 Aug;34(8):410-22. doi: 10.1016/j.it.2013.04.006. Epub 2013 May 21.

Modeling the heterogeneity of multiple sclerosis in animals.

Author information

1
Department of Immunology, University of Washington, Seattle, WA 98195, USA.

Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) manifested with varying clinical course, pathology, and inflammatory patterns. There are multiple animal models that reflect different aspects of this heterogeneity. Collectively, these models reveal a balance between pathogenic and regulatory CD4(+) T cells, CD8(+) T cells, and B cells that influences the incidence, timing, and severity of CNS autoimmunity. In this review we discuss experimental autoimmune encephalomyelitis (EAE) models that have been used to study the pathogenic and regulatory roles of these immune cells; models that recapitulate different aspects of the disease seen in patients with MS, and questions remaining for future studies.

KEYWORDS:

animal models; autoimmunity; experimental autoimmune encephalomyelitis; multiple sclerosis; neuroimmunology

PMID:
23707039
PMCID:
PMC3752929
DOI:
10.1016/j.it.2013.04.006
[Indexed for MEDLINE]
Free PMC Article

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