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Virol J. 2013 May 26;10:163. doi: 10.1186/1743-422X-10-163.

Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca).

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1
College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.

Abstract

BACKGROUND:

In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China.

RESULTS:

Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus.

CONCLUSIONS:

These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores.

PMID:
23706032
PMCID:
PMC3680276
DOI:
10.1186/1743-422X-10-163
[Indexed for MEDLINE]
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