Send to

Choose Destination
J Clin Biochem Nutr. 2013 May;52(3):186-92. doi: 10.3164/jcbn.12-130. Epub 2013 Apr 19.

Flavan 3-ols improve metabolic syndrome risk factors: evidence and mechanisms.

Author information

Department of Bio-science and Engineering, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.

Erratum in

  • J Clin Biochem Nutr. 2013 Jul;53(1):73.


Flavan 3-ols, a type of polyphenolic substance, are distributed in a number of plant foods. Of these foods, chocolate is very rich in flavan 3-ols as flavan 3-ol monomers, (+)-catechin and (-)-epicatechin, and the oligomers as procyanidins. There is evidence that cacao products containing flavan 3-ols have the potential to contribute to the risk reduction of cardiometabolic disorders according to recent epidemiological or intervention studies. This review focuses on recent advances in research on the ability of flavan 3-ols to reduce the risk of cardiovascular disease as a result of improving metabolic syndrome risk factors and these mechanisms.


cardiovascular diseases; chocolate; flavan 3-ols; metabolic syndrome; risk factors

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic Icon for PubMed Central
Loading ...
Support Center