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Circ Res. 2013 May 24;112(11):1506-19. doi: 10.1161/CIRCRESAHA.113.300512.

Platelets as cellular effectors of inflammation in vascular diseases.

Author information

1
Department of Medicine and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

Abstract

Platelets are chief effector cells in hemostasis. In addition, they are multifaceted inflammatory cells with functions that span the continuum from innate immune responses to adaptive immunity. Activated platelets have key thromboinflammatory activities in a variety of vascular disorders and vasculopathies. Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.

KEYWORDS:

immune responses; inflammation; platelets; vasculopathy; vessel diseases

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PMID:
23704217
PMCID:
PMC3738064
DOI:
10.1161/CIRCRESAHA.113.300512
[Indexed for MEDLINE]
Free PMC Article

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