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Chembiochem. 2013 Jun 17;14(9):1068-71. doi: 10.1002/cbic.201300129. Epub 2013 May 22.

Fluorescent probes for live cell imaging of endogenous Guanine nitration.

Author information

1
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai 980-8577, Japan.

Abstract

Seeing is believing: S-guanylation is a novel key mechanism by which signal transduction under oxidative stress is regulated. A chemical probe whose fluorescent intensity increases after the reaction with proteinous cysteine (S-guanylation) is described. The use of this probe revealed that S-guanylation products localized in lysosomes.

PMID:
23703929
DOI:
10.1002/cbic.201300129
[Indexed for MEDLINE]

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