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J Am Med Inform Assoc. 2013 Sep-Oct;20(5):947-53. doi: 10.1136/amiajnl-2013-001708. Epub 2013 May 23.

Dictionary construction and identification of possible adverse drug events in Danish clinical narrative text.

Author information

1
Department of Disease Systems Biology, Faculty of Health and Medical Sciences, NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.

Abstract

OBJECTIVE:

Drugs have tremendous potential to cure and relieve disease, but the risk of unintended effects is always present. Healthcare providers increasingly record data in electronic patient records (EPRs), in which we aim to identify possible adverse events (AEs) and, specifically, possible adverse drug events (ADEs).

MATERIALS AND METHODS:

Based on the undesirable effects section from the summary of product characteristics (SPC) of 7446 drugs, we have built a Danish ADE dictionary. Starting from this dictionary we have developed a pipeline for identifying possible ADEs in unstructured clinical narrative text. We use a named entity recognition (NER) tagger to identify dictionary matches in the text and post-coordination rules to construct ADE compound terms. Finally, we apply post-processing rules and filters to handle, for example, negations and sentences about subjects other than the patient. Moreover, this method allows synonyms to be identified and anatomical location descriptions can be merged to allow appropriate grouping of effects in the same location.

RESULTS:

The method identified 1 970 731 (35 477 unique) possible ADEs in a large corpus of 6011 psychiatric hospital patient records. Validation was performed through manual inspection of possible ADEs, resulting in precision of 89% and recall of 75%.

DISCUSSION:

The presented dictionary-building method could be used to construct other ADE dictionaries. The complication of compound words in Germanic languages was addressed. Additionally, the synonym and anatomical location collapse improve the method.

CONCLUSIONS:

The developed dictionary and method can be used to identify possible ADEs in Danish clinical narratives.

KEYWORDS:

Adverse Drug Event; Adverse Drug Reaction Reporting Systems; Data Mining; Dictionary; Electronic Health Records

PMID:
23703825
PMCID:
PMC3756275
DOI:
10.1136/amiajnl-2013-001708
[Indexed for MEDLINE]
Free PMC Article
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