Format

Send to

Choose Destination
See comment in PubMed Commons below
Biopolymers. 2013 Oct;99(10):697-712. doi: 10.1002/bip.22290.

Amphiphilic cytosolic glycans from mycobacteria: occurrence, lipid-binding properties, biosynthesis, and synthesis.

Author information

1
Alberta Glycomics Centre and Department of Chemistry, University of Alberta, Gunning-Lemieux Chemistry Centre, Edmonton, AB T6G 2G2, Canada.

Abstract

Polymethylated polysaccharides (PMPSs), glycans composed of 10-20 carbohydrate residues the majority of which carry a single methyl group, are produced by some mycobacterial species. O-Methylation thus occurs on 20-30% of all the hydroxyl groups within the molecule, rendering them amphiphilic. A property of PMPSs is their ability to form high-affinity complexes with fatty acids and their derivatives, suggesting a role in mycobacterial fatty acid biosynthesis. However, direct evidence for their in vivo function is still lacking. Over the past several decades the lipid-binding properties, biosynthesis, and chemical synthesis of PMPSs have been explored and this review will provide an overview of progress made in these areas.

KEYWORDS:

amphiphilic; biosynthesis; lipid-binding; mycobacterial glycans; synthesis

PMID:
23703393
DOI:
10.1002/bip.22290
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center