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Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459.

Immunology of age-related macular degeneration.

Author information

1
Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA. jamba2@email.uky.edu

Abstract

Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.

PMID:
23702979
PMCID:
PMC3941009
DOI:
10.1038/nri3459
[Indexed for MEDLINE]
Free PMC Article

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