Format

Send to

Choose Destination
Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452.

Activation and regulation of the inflammasomes.

Author information

1
Institute of Innate Immunity, University Hospital, University of Bonn, Bonn 53127, Germany. eicke.latz@uni-bonn.de

Abstract

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.

PMID:
23702978
PMCID:
PMC3807999
DOI:
10.1038/nri3452
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center