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Endocrinol Metab Clin North Am. 2013 Jun;42(2):349-70. doi: 10.1016/j.ecl.2013.02.005. Epub 2013 Apr 17.

Age-associated abnormalities of water homeostasis.

Author information

1
Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20007, USA.

Abstract

Findley first proposed the presence of age-related dysfunction of the hypothalamic-neurohypophyseal-renal axis more than 60 years ago. More sophisticated studies have since corroborated his findings. As a result, it is now clear that multiple abnormalities in water homeostasis occur commonly with aging, and that the elderly are uniquely susceptible to disorders of body volume and osmolality. This article summarizes the distinct points along the hypothalamic-neurohypophyseal-renal axis where these changes have been characterized, as well as the clinical significance of these changes, with special attention to effects on cognition, gait instability, osteoporosis, fractures, and morbidity and mortality.

PMID:
23702406
PMCID:
PMC3682932
DOI:
10.1016/j.ecl.2013.02.005
[Indexed for MEDLINE]
Free PMC Article

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