Format

Send to

Choose Destination
Curr Opin Neurobiol. 2013 Oct;23(5):873-9. doi: 10.1016/j.conb.2013.04.014. Epub 2013 May 20.

Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function.

Author information

1
Department of Anesthesia, University of California San Francisco, San Francisco, CA 94143, United States.

Abstract

Why do we need to sleep? What regulates when we sleep? And what dictates the number of hours we require? These are often viewed as three separate biological questions. Here, we propose they share molecular etiologies, whereby regulators of sleep schedules and sleep duration also govern the physiological purposes of sleep. To support our hypothesis, we review Mendelian human genetic variants sufficient to advance sleep-wake onset (PER2) and shorten sleep length (DEC2), and evaluate their emerging roles in immune responses that may rely on a sound night of slumber.

PMID:
23702243
PMCID:
PMC3766463
DOI:
10.1016/j.conb.2013.04.014
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center