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Curr Biol. 2013 May 20;23(10):R456-9. doi: 10.1016/j.cub.2013.04.033.

Chromatin: a tail of repression.

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1
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. danesh_moazed@hms.harvard.edu

Abstract

Genetic evidence on the role of specific histone amino acids or their posttranslational modifications in metazoan development has been lacking. A recent study reports that fruit flies carrying histone H3 lysine 27 (H3K27) mutations have the same homeotic gene expression and developmental defects as mutations in the enzyme that trimethylates H3K27.

PMID:
23701691
DOI:
10.1016/j.cub.2013.04.033
[Indexed for MEDLINE]
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