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J Enzyme Inhib Med Chem. 2014 Jun;29(3):443-8. doi: 10.3109/14756366.2013.795957. Epub 2013 May 23.

Synthesis and hypoglycemic activity of some new theophylline derivatives.

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1
Department of Pharmaceutical Chemistry and.

Abstract

Thirty-one new theophylline derivatives have been synthesized and evaluated for their hypoglycemic activity. Compounds 24 (56% reduction) and 31 (57% reduction) showed better hypoglycemic activity than the standard drug glibenclamide which showed 52% reduction in serum glucose level. Compound 27 remarkably reduced serum glucose level by 53%. Ten compounds showed varying degrees of hypoglycemic activity ranging from 20 to 37% reduction in serum glucose level compared to the standard drug. The aromatic amide functionality is the common feature of these theophylline hypoglycemic derivatives. However, anthranilamide and or aliphatic amides proved to be the least active compounds in the present series.

KEYWORDS:

Hypoglycemic; isoindoline; synthesis; theophylline

PMID:
23701264
DOI:
10.3109/14756366.2013.795957
[Indexed for MEDLINE]
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