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Adipocyte. 2013 Jan 1;2(1):3-6.

New players on the metabolic stage: How do you like Them Acots?

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Department of Medicine; Division of Gastroenterology; Brigham and Women's Hospital; Harvard Medical School; Boston, MA USA.


Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly upregulated when mice are exposed to cold ambient temperatures. In a recent study, we demonstrated that Them1-/- mice exhibit increased energy expenditure and are resistant to diet-induced obesity and its metabolic consequences. This mini-review places these findings in the context of an emerging understanding of Them/Acot genes.


brown adipose tissue; enzyme; fatty acyl-CoA; lipid binding protein; liver

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