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Adipocyte. 2012 Oct 1;1(4):200-202.

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines.

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Department of Physiology and Center for Metabolism and Obesity Research; The Johns Hopkins University School of Medicine; Baltimore, MD USA.


The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk.


CTRP15; FABP; FATP; energy balance; fatty acids; lipid uptake; myokine; myonectin; skeletal muscle

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