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Genes Dev. 2013 May 15;27(10):1073-8. doi: 10.1101/gad.220178.113.

A small RNA serving both the Hfq and CsrA regulons.

Author information

1
Institute for Molecular Infection Biology, University of Würzburg, D-97080 Würzburg, Germany.

Abstract

The abundant RNA-binding proteins CsrA and Hfq each impact bacterial physiology by working in conjunction with small RNAs to control large post-transcriptional regulons. The small RNAs involved were considered mechanistically distinct, regulating mRNAs either directly through Hfq-mediated base-pairing or indirectly by sequestering the global translational repressor CsrA. In this issue of Genes & Development, Jørgensen and colleagues (pp. 1132-1145) blur these distinctions with a dual-mechanism small RNA that acts through both Hfq and CsrA to regulate the formation of bacterial biofilms.

KEYWORDS:

CsrA; CsrB; Hfq; PGA; c-di-GMP

PMID:
23699406
PMCID:
PMC3672642
DOI:
10.1101/gad.220178.113
[Indexed for MEDLINE]
Free PMC Article

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