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Nat Rev Mol Cell Biol. 2013 Jun;14(6):341-56. doi: 10.1038/nrm3589.

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription.

Author information

1
Sanford Consortium for Regenerative Medicine and La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA. wpastor@ucla.edu

Abstract

In many organisms, the methylation of cytosine in DNA has a key role in silencing 'parasitic' DNA elements, regulating transcription and establishing cellular identity. The recent discovery that ten-eleven translocation (TET) proteins are 5-methylcytosine oxidases has provided several chemically plausible pathways for the reversal of DNA methylation, thus triggering a paradigm shift in our understanding of how changes in DNA methylation are coupled to cell differentiation, embryonic development and cancer.

PMID:
23698584
PMCID:
PMC3804139
DOI:
10.1038/nrm3589
[Indexed for MEDLINE]
Free PMC Article

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