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Nat Rev Mol Cell Biol. 2013 Jun;14(6):329-40. doi: 10.1038/nrm3591.

Molecular regulation of stem cell quiescence.

Author information

  • 1Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of time. This state, which is reversible, has long been viewed as dormant and with minimal basal activity. Recent advances in adult stem cell isolation have provided insights into the epigenetic, transcriptional and post-transcriptional control of quiescence and suggest that quiescence is an actively maintained state in which signalling pathways are involved in maintaining a poised state that allows rapid activation. Deciphering the molecular mechanisms regulating adult stem cell quiescence will increase our understanding of tissue regeneration mechanisms and how they are dysregulated in pathological conditions and in ageing.

PMID:
23698583
PMCID:
PMC3808888
DOI:
10.1038/nrm3591
[PubMed - indexed for MEDLINE]
Free PMC Article
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