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Viruses. 2013 May 22;5(5):1272-91. doi: 10.3390/v5051272.

The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection.

Author information

1
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld. 33, 33 North Drive, Bethesda, MD 20892, USA. jvogel@niaid.nih.gov

Abstract

Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1). This review focuses on the multiple chromatin modulation components associated with HCF-1 and the chromatin-related dynamics mediated by this coactivator that lead to the initiation of herpes simplex virus (HSV) immediate early gene expression.

PMID:
23698399
PMCID:
PMC3712308
DOI:
10.3390/v5051272
[Indexed for MEDLINE]
Free PMC Article

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